Devils tried Hughes on Hischier's wing at times in his 1st year, results were terribly unimpressive. That's when Jack Hughes looked his worst and the 'bust' moniker genuinely felt true at times during that period.
Besides, the Devils have so many top notch wingers at this point in time that shifting Hughes to the wing achieves nothing whatsoever.
Hughes and Hischier do play together on the powerplay and when the Devils pull the goalie and, while they do look great together in those scenarios at 5v5 fate has deemed that they should be played separately and that's probably for the best.

Hughes needs as much ice as possible to operate. Gotta stay in the middle.

Keep Jack and Nico on separate lines unless its the powerplay. Those 2 together 5on5 don't work well together which is weird. The lines for the top 6 I'd like to see them try are:

Meier-Hughes-Mercer
Bratt-Hischier-Toffoli

The Hughes line is from games 4&5 vs Carolina in the playoffs and that's when Meier got going. Plus Bratt and Hischier have played together a lot over the years and have chemistry.

This is a really bad idea

Jack is a center for a reason imo