Balance your buildings. While some buildings may seem more powerful or expensive than others, they all have their pros and cons and can work together to boost cookie clicker 2.
Cursors and grandmas are cheap and have many synergies with other buildings and upgrades, while prisms and chancemakers are costly but have high production rates and can benefit from the kitten upgrades. You should try to balance your buildings and not neglect any of them, as they can all contribute to your cookie empire.